M1-C2-L39 --> Drug Metabolism
Terms
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- Ingesting grapefruit with antihistamines can lead to what?
- Fatal Cardiac Arrhythmia
- What are the factors affecting drug metabolism? x 9
-
1. Sex
2. Co-morbidity
3. Age
4. Nutritional status (fasting, starvation)
5. Smoking (EtOH, caffeine)
6. Genetic polymorphism
7. Obesity
8. Other drugs
9. Diet - Rifampin and phenobarbital does what drug metabolism?
- Induces drug metabolism.
- St. John's Wort does what to drug metabolism?
- Induces drug metabolism.
- Chronic EtOH and smoking does what to drug metabolism?
- Induces drug metabolism
- What type of foods would induce drug metabolism?
- Cruciferous vegetables, garlic, and citrus.
- How does fasting induce drug metabolism?
- Induces P4502E1
- Cimetidine and ketoconazole does what to drug metabolism?
- Inhibits drug metabolism
- What does Dong Quai do to drug metabolism?
- Inhibits drug metabolism
- What type of foods would inhibit drug metabolism?
- Grapefruit and garlic
- How does fasting inhibit drug metabolism?
- Depletes cofactors necessary for metabolism.
- Biotransformation is used synonymously with what word when referring to drugs?
- Metabolism
- Where do drug biotransformation occur?
- In the liver
- Phase I metabolism usually occurs where?
- sER
- What are the major reactions of Phase I metabolism?
-
Hydrolysis
Oxidation
Reduction